Computational study of cell adhesion and rolling in flow channel by meshfree method
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15 صفحه اولBiomechanics of cell rolling: shear flow, cell-surface adhesion, and cell deformability.
The mechanics of leukocyte (white blood cell; WBC) deformation and adhesion to endothelial cells (EC) has been investigated using a novel in vitro side-view flow assay. HL-60 cell rolling adhesion to surface-immobilized P-selectin was used to model the WBC-EC adhesion process. Changes in flow shear stress, cell deformability, or substrate ligand strength resulted in significant changes in the c...
متن کاملThe state diagram for cell adhesion under flow: leukocyte rolling and firm adhesion.
Leukocyte adhesion under flow in the microvasculature is mediated by binding between cell surface receptors and complementary ligands expressed on the surface of the endothelium. Leukocytes adhere to endothelium in a two-step mechanism: rolling (primarily mediated by selectins) followed by firm adhesion (primarily mediated by integrins). Using a computational method called "Adhesive Dynamics," ...
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ژورنال
عنوان ژورنال: Computer Methods in Biomechanics and Biomedical Engineering
سال: 2017
ISSN: 1025-5842,1476-8259
DOI: 10.1080/10255842.2017.1303051